Mieloma Multiple - Mieloma.com

Mieloma Novedades en investigacion mayo 2007
 
Fuente y mas informacion:
MYELOMA MINUTE - MAY 22, 2007
http://readtheminute.myeloma.org/

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      Myeloma bone disease and proteasome inhibition therapies
http://bloodjournal.hematologylibra...007-03-067710v1
      Evangelos Terpos, Orhan Sezer*, Peter Croucher, and Meletios-Athanassios Dimopoulos*
      Blood published 9 May 2007, 10.1182/blood-2007-03-067710

    * The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
http://bloodjournal.hematologylibra...act/109/10/4470
      Simona Colla, Fenghuang Zhan, Wei Xiong, Xiaosong Wu, Hongwei Xu, Owen Stephens, Shmuel Yaccoby, Joshua Epstein, Bart Barlogie*, and John D. Shaughnessy, Jr
      Blood 2007;109 4470-4477

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      Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01)lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation
http://bloodjournal.hematologylibra...act/109/10/4415
      Yun Dai, Payal Khanna, Shuang Chen, Xin-Yan Pei, Paul Dent, and Steven Grant
      Blood 2007;109 4415-4423

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      High serum free-light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis
http://bloodjournal.hematologylibra...007-01-067728v2
      Frits van Rhee, Vanessa Bolejack, Klaus Hollmig, Mauricio Pineda-Roman, Elias Anaissie, Joshua Epstein, John D Shaughnessy, Jr, Maurizio Zangari, Guido Tricot*, Abid Mohiuddin, Yazan Alsayed, Gail Woods, John Crowley*, and Bart Barlogie*
      Blood published 30 April 2007, 10.1182/blood-2007-01-067728

    * Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth
http://bloodjournal.hematologylibra...006-08-042374v1
      Haiming Chen, Melinda S Gordon, Richard A Campbell, Mingjie Li, Cathy S Wang, Hee Jin Lee, Eric Sanchez, Steven J Manyak, Dorina Gui, Dror Shalitin, Jonathan Said, Yunchao Chang, Thomas F Deuel, Stavroula Baritaki, Benjamin Bonavida, and James R Berenson*
      Blood published 16 March 2007, 10.1182/blood-2006-08-042374

    * Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
http://bloodjournal.hematologylibra...007-03-081133v1
      Dennis Loffler, Katja Brocke-Heidrich, Gabriele Pfeifer, Claudia Stocsits, Jorg Hackermuller, Antje K. Kretzschmar, Renate Burger, Martin Gramatzki, Conny Blumert, Kay Bauer, Helena Cvijic, A. Kerstin Ullmann, Peter F. Stadler, and Friedemann Horn
      Blood published 11 May 2007, 10.1182/blood-2007-03-081133

    * Targeting MEK induces myeloma cell cytotoxicity and inhibits osteoclastogenesis
http://bloodjournal.hematologylibra...007-03-081240v1
      Yu-Tzu Tai, Mariateresa Fulciniti, Teru Hideshima, Weihua Song, Merav Leiba, Xian-Feng Li, Matthew Rumizen, Peter Burger, Aileen Morrison, Klaus Podar, Dharminder Chauhan, Pierfrancesco Tassone, Paul Richardson, Nikhil C Munshi, Irene Ghobrial, and Kenneth C Anderson
      Blood published 17 May 2007, 10.1182/blood-2007-03-081240





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 17 May 2007 11:42:39 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Blood. 2007 May 9
    Myeloma bone disease and proteasome inhibition therapies
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Terpos E, Sezer O, Croucher P, Dimopoulos MA

    Cancer Sci. 2007 May 4
    Serum M-spike and transplant outcome in patients with multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Dingli D, Pacheco JM, Dispenzieri A, Hayman SR, Kumar SK, Lacy MQ, Gastineau DA, Gertz MA

    Br J Haematol. 2007 May 9
    Testing standard and genetic parameters in 220 patients with multiple myeloma with complete data sets: superiority of molecular genetics
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Shaughnessy JD Jr, Haessler J, van Rhee F, Anaissie E, Pineda-Roman M, Cottler-Fox M, Hollmig K, Zangari M, Mohiuddin A, Alsayed Y, Grazziutti M, Epstein J, Crowley J, Barlogie B

    Haematologica. 2007 Apr
    Reversibility of renal failure in newly diagnosed multiple myeloma patients treated with high dose dexamethasone-containing regimens and the impact of novel agents
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Kastritis E, Anagnostopoulos A, Roussou M, Gika D, Matsouka C, Barmparousi D, Grapsa I, Psimenou E, Bamias A, Dimopoulos MA





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 10 May 2007 13:10:42 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    J Clin Oncol. 2007 May 7
    Prospective, Randomized Study of Single Compared With Double Autologous Stem-Cell Transplantation for Multiple Myeloma: Bologna 96 Clinical Study
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Cavo M, Tosi P, Zamagni E, Cellini C, Tacchetti P, Patriarca F, Di Raimondo F, Volpe E, Ronconi S, Cangini D, Narni F, Carubelli A, Masini L, Catalano L, Fiacchini M, de Vivo A, Gozzetti A, Lazzaro A, Tura S, Baccarani M

    Front Biosci. 2007 May 1
    Reduced intensity allogeneic stem cell transplantation in multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Bensinger WI

    Front Biosci. 2007 May 1
    Dendritic cell vaccine but not idiotype-KLH protein vaccine primes therapeutic tumor-specific immunity against multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Wang S, Hong S, Wezeman M, Qian J, Yang J, Yi Q





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 5 Apr 2007 12:41:16 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Exp Hematol. 2007 Apr
    Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Anderson KC

    Blood Rev. 2007 Mar 15
    Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Rajkumar SV, Lacy MQ, Kyle RA

    Leukemia. 2007 Mar 22
    Thalidomide in newly diagnosed multiple myeloma: influence of thalidomide treatment on peripheral blood stem cell collection yield
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Breitkreutz I, Lokhorst HM, Raab MS, Holt BV, Cremer FW, Herrmann D, Glasmacher A, Schmidt-Wolf IG, Blau IW, Martin H, Salwender H, Haenel A, Sonneveld P, Goldschmidt H

    Bone Marrow Transplant. 2007 Mar 19
    Impact of age and serum creatinine value on outcome after autologous blood stem cell transplantation for patients with multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Gertz MA, Lacy MQ, Dispenzieri A, Hayman SR, Kumar S, Leung N, Gastineau DA





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 26 Apr 2007 13:14:59 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Best Pract Res Clin Haematol. 2007 Jun
    Risk assessment in haematopoietic stem cell transplantation: Impact of donor-recipient sex combination in allogeneic transplantation
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Gahrton G

    Cancer. 2007 Apr 17
    Limited feasibility of double transplant in multiple myeloma: results of a multicenter study on 153 patients aged <65 years
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Corso A, Mangiacavalli S, Barbarano L, Alessandrino EP, Cairoli R, Morra E, Lazzarino M

    Biol Blood Marrow Transplant. 2007 May
    Results of a Retrospective Single Institution Analysis of Targeted Skeletal Radiotherapy with (166)Holmium-DOTMP as Conditioning Regimen for Autologous Stem Cell Transplant for Patients with Multiple Myeloma. Impact on Transplant Outcomes
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Christoforidou AV, Saliba RM, Williams P, Qazilbash M, Roden L, Aleman A, Weber D, Mendoza F, Podoloff D, Wendt R 3rd, Breitz H, Alexanian R, Champlin R, Giralt S

    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Apr 19
    Bisphosphonates and osteonecrosis of the jaws: Science and rationale
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Gutta R, Louis PJ





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 3 May 2007 12:43:52 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Leuk Lymphoma. 2007 Mar
    The treatment of the elderly multiple myeloma patients
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Cavallo F, Ambrosini MT, Rus C, Boccadoro M, Palumbo A


    Br J Haematol. 2007 Apr 19
    Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, San Miguel JF, Cavenagh JD, Anderson KC


    Hematology. 2007 Apr
    Collection of peripheral blood stem cells in new patients with myeloma receiving minimal or no prior cytoreductive therapy
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Sirohi B, Powles R, Cavanagh J, Oakervee H, Dyer P, Rintala T, Kulkarni S, Rudin C, Horton C, Treleaven J, Morgan G


    Leuk Lymphoma. 2007 Apr
    Pulsed cyclophosphamide, thalidomide and dexamethasone regimen for previously treated patients with multiple myeloma: Long term follow up and disease control after subsequent treatments
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Roussou M, Anagnostopoulos A, Kastritis E, Matsouka C, Barmparousi D, Koutsoukou V, Dimopoulos MA





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:

Myeloma Minute - May 1, 2007
http://readtheminute.myeloma.org/

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      Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
http://bloodjournal.hematologylibra...full/109/8/3177
      George Mulligan, Constantine Mitsiades, Barb Bryant, Fenghuang Zhan, Wee J. Chng, Steven Roels, Erik Koenig, Andrew Fergus, Yongsheng Huang, Paul Richardson*, William L. Trepicchio, Annemiek Broyl, Pieter Sonneveld*, John D. Shaughnessy, Jr, P. Leif Bergsagel*, David Schenkein, Dixie-Lee Esseltine, Anthony Boral, and Kenneth C. Anderson*
      Blood, 15 April 2007, Vol. 109, No. 8, pp. 3177-3188.

    * Genomics in myeloma: the philosopher's stone?
http://bloodjournal.hematologylibra...09/8/3126?rss=1
      Andreas Rosenwald
      Blood 2007;109 3126
      A comment on the article above.

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      High serum free-light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis
http://bloodjournal.hematologylibra...007-01-067728v1
      Frits van Rhee, Vanessa Bolejack, Klaus Hollmig, Mauricio Pineda-Roman, Elias Anaissie, Joshua Epstein, John D Shaughnessy, Jr, Maurizio Zangari, Abid Mohiuddin, Yazan Alsayed, Gail Woods, John Crowley*, and Bart Barlogie*
      Blood published 6 April 2007, 10.1182/blood-2007-01-067728

    *

      Targeting aurora kinases as therapy in multiple myeloma
http://bloodjournal.hematologylibra...ract/109/9/3915
      Yijiang Shi, Tony Reiman, Weiqun Li, Christopher A. Maxwell, Subrata Sen, Linda Pilarski*, Tracy R. Daniels, Manuel L. Penichet, Rick Feldman, and Alan Lichtenstein
      Blood 2007;109 3915-3921

    * Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
http://bloodjournal.hematologylibra...ract/109/9/3849
      Frederic Luciano, Maryla Krajewska, Paulina Ortiz-Rubio, Stan Krajewski, Dayong Zhai, Benjamin Faustin, Jean-Marie Bruey, Beatrice Bailly-Maitre, Alan Lichtenstein, Siva Kumar Kolluri, Arnold C. Satterthwait, Xiao-Kun Zhang, and John C. Reed
      Blood 2007;109 3849-3855

    * Multiple myeloma and FISH (but no CHIPS)
http://bloodjournal.hematologylibra...full/109/8/3132
      Rafael Fonseca*
      Blood 2007;109 3132-3133

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      Nonmyeloablative allotransplantation for myeloma: light and shade
http://bloodjournal.hematologylibra...09/8/3134?rss=1
      Michele Cavo
      Blood 2007;109 3134-3135

    * Integrated molecular profiling of SOD2 expression in multiple myeloma
http://bloodjournal.hematologylibra...006-07-035162v1
      Elaine M. Hurt, Suneetha B. Thomas, Benjamin Peng, and William L. Farrar
      Blood 2007;109 3953-3962





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

GRACIAS VICTOR
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