Mieloma Novedades en investigacion noviembre 2007

Fuente y mas informacion:
Myeloma Minute - November 21, 2007
http://readtheminute.myeloma.org/



    * Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
http://bloodjournal.hematologylibra...05601v1?papetoc
      Dharminder Chauhan, Ajita Singh, Mohan Brahmandam, Klaus Podar, Teru Hideshima, Paul Richardson*, Nikhil Munshi, Michael A. Palladino, and Kenneth C. Anderson*
      Blood published 15 November 2007, 10.1182/blood-2007-08-105601

    * The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that may benefit from aurora kinase inhibition
http://bloodjournal.hematologylibra...97774v1?papetoc
      Wee J Chng, Esteben Braggio, George Mulligan, Barbara Bryant, Ellen Remstein, Riccardo Valdez, Ahment Dogan, and Rafael Fonseca*
      Blood published 15 November 2007, 10.1182/blood-2007-06-097774

    * The Y-box binding protein YB-1 is associated with progressive disease and mediates survival and drug resistance in multiple myeloma
http://bloodjournal.hematologylibra...89151v1?papetoc
      Manik Chatterjee, Christoph Rancso, Thorsten Stuhmer, Niels Eckstein,? Mindaugas Andrulis, Christian Gerecke, Heike Lorentz, Hans-Dieter Royer, and Ralf C Bargou
      Blood published 15 November 2007, 10.1182/blood-2007-05-089151

    * Single autologous stem cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial
http://bloodjournal.hematologylibra...007-07-101212v3
      Abderrahman Abdelkefi, Saloua Ladeb, Lamia Torjman, Tarek Ben Othman, Amel Lakhal, Neila Ben Romdhane, Halima El Omri, Moez Elloumi, Hatem Belaaj, Ramzi Jeddi, Lamia Aissaoui, Habib Ksouri, Assia Ben Hassen, Fahmi Msadek, Ali Saad, Mohamed Hsairi, Kamel Boukef, Ahlem Amouri, Hechmi Louzir, Koussay Dellagi, and Abdeladhim Ben Abdeladhim Blood published 8 November 2007, 10.1182/blood-2007-07-101212





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 15 Nov 2007 12:50:20 -0600 (CST)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    * Blood. 2007 Nov 7
      BiRD(Biaxin(R)[clarithromycin]/Revlimid(R) [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum
      Niesvizky R, Jayabalan DS, Christos PJ, Furst JR, Naib T, Ely S, Jalbrzikowski J, Pearse RN, Zafar F, Pekle K, Larow A, Lent R, Mark T, Cho HJ, Shore T, Tepler J, Harpel J, Schuster MW, Mathew S, Leonard JP, Mazumdar M, Chen-Kiang S, Coleman M.

    * J Clin Oncol. 2007 Nov 1
      Relationship between depth of response and outcome in multiple myeloma
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum
      Dingli D, Pacheco JM, Nowakowski GS, Kumar SK, Dispenzieri A, Hayman SR, Lacy MQ, Gastineau DA, Gertz MA.

    * Leukemia. 2007 Nov 1
      Rituximab in CD20 positive multiple myeloma
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum
      Bergua JM, Cabrera C, Arteta EG, Prieto J.

    * Drug News Perspect. 2007 Sep
      Treatment of multiple myeloma with SDX-308
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum
      Feng R, Lentzsch S.





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Hola V?ctor,
Veo que, aparte de consolidarse los nuevos tratamientos, bortezomid, talidomina, aparecen otros nuevos vomo el:

YB-1
BiRD(Biaxin(R)[clarithromycin]/Revlimid(R) [lenalidomide]/dexamethason (ya comentado en este foro)
Rituximad
SDX-308 ?ste en fase pre-cl?nica, (experimentaci?n en animales) pero que seg?n parece se est?n obteniendo magn?ficos resultados, por lo que pronto se iniciar? la experimentaci?n humana.

Para los que tengan dudas de las distintas fases de un ensayo cl?nico, pongo el link de la explicaci?n de en qu? consiste y las fases obligatorias que tiene:

http://es.wikipedia.org/wiki/Ensayo_cl%C3%ADnico-

Lo importante es que se siga investigando...

Muchas gracias, Mar?a!
un beso.