Mieloma Multiple - Mieloma.com

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

     Myeloma Minute - June 30, 2006
 Myeloma Minute - July 7, 2006
http://readtheminute.myeloma.org/



Plasma cell quantification in bone marrow by computer-assisted image analysis.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Went P, Mayer S, Oberholzer M, Dirnhofer S.
Histol Histopathol. 2006 Sep;21(9):951-6.

High-dose melphalan (200 mg/m2) supported by autologous stem cell transplantation is safe and effective in elderly (>or=65 years) myeloma patients: comparison with younger patients treated on the same protocol.
http://www.nature.com/bmt/journal/v...259565E49843C60
Jantunen E, Kuittinen T, Penttila K, Lehtonen P, Mahlamaki E, Nousiainen T.
Bone Marrow Transplantation (2006) 37, 917-922.

Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications
http://www.bloodjournal.org/cgi/content/abstract/108/2/618?etoc
David H. Chang, Nancy Liu, Virginia Klimek, Hani Hassoun, Amitabha Mazumder, Stephen D. Nimer, Sundar Jagannath*, and Madhav V. Dhodapkar
Blood 2006;108 618-621

Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea:  biological activity and therapeutic implications
http://www.bloodjournal.org/cgi/con...22814v1?papetoc
Masood A Shammas, Paola Neri, Hemanta Koley, Ramesh B Batchu, Robert C Bertheau, Vidit Munshi, Rao Prabhala, Mariateresa Fulciniti, Yu tzu Tai, Steven P Treon, Raj K Goyal, Kenneth C Anderson*, and Nikhil C Munshi
Blood published 29 June 2006, 10.1182/blood-2006-05-022814





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

    The Myeloma Minute - September 22, 2006
http://readtheminute.myeloma.org/


      Complete response in myeloma: a Trojan horse?
http://www.bloodjournal.org/cgi/content/full/108/7/2134?etoc
      Bart Barlogie* and Guido Tricot*
      Blood 2006;108 2134



      Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma
http://www.bloodjournal.org/cgi/content/abstract/108/7/2159?etoc
      Massimo Offidani, Laura Corvatta, Maria-Novella Piersantelli, Giuseppe Visani, Francesco Alesiani, Marino Brunori, Piero Galieni, Massimo Catarini, Maurizio Burattini, Riccardo Centurioni, Mario Ferranti, Serena Rupoli, Anna Rita Scortechini, Luciano Giuliodori, Marco Candela, Debora Capelli, Mauro Montanari, Attilio Olivieri, Antonella Poloni, Claudia Polloni, Monica Marconi, and Pietro Leoni
      Blood 2006;108 2159-2164

    

      Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study
http://www.bloodjournal.org/cgi/content/abstract/108/7/2165
      Maria-Victoria Mateos, Jose-M. Hernandez, Miguel-T. Hernandez, Norma-C. Gutierrez, Luis Palomera, Marta Fuertes, Joaquin Diaz-Mediavilla, Juan-J. Lahuerta, Javier de la Rubia, Maria-Jose Terol, Ana Sureda, Joan Bargay, Paz Ribas, Felipe de Arriba, Adrian Alegre, Albert Oriol, Dolores Carrera, Jose Garcia-Larana, Ramon Garcia-Sanz, Joan Blade, Felipe Prosper, Gemma Mateo, Dixie-Lee Esseltine, Helgi van de Velde, and Jesus F. San Miguel*
      Blood 2006;108 2165-2172





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

     The Myeloma Minute - September 14, 2006
http://readtheminute.myeloma.org/


    *  Current Issue of Journal of Medicinal Chemistry Highlights Advantages of Infinity's Lead Oncology Drug Candidate, IPI-504
http://www.medicalnewstoday.com/medicalnews.php?newsid=48195
      Journal of Medicinal Chemistry (Volume 49, Issue 15 (July 27, 2006), pages 4606-4615
      (from Medical News Today)

    * Monoclonal gammopathy of undetermined significance.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
      Kyle, RA*, Vincent Rajkumar S*.
      Br J Haematol. 2006 Sep;134(6):573-89.

    *

      Cannabis-Based Treatment Effective in Neuropathic Pain and Spasticity
http://www.docguide.com/news/conten...52571E300565354
      Researchers from Glasgow University, UK presented the findings at the 10th Congress of the European Federation of Neurological Societies (EFNS).

    * Immunoglobulin free light chains and solitary plasmacytoma of bone
http://www.bloodjournal.org/cgi/content/abstract/108/6/1979
      David Dingli, Robert A. Kyle*, S. Vincent Rajkumar*, Grzegorz S. Nowakowski, Dirk R. Larson, John P. Bida, Morie A. Gertz*, Terry M. Therneau, L. Joseph Melton, III, Angela Dispenzieri, and Jerry A. Katzmann
      Blood 2006;108 1979-1983

    * Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials
http://www.bloodjournal.org/cgi/con...ourcetype=HWCIT
      Mark Drayson, Gulnaz Begum, Supratik Basu, Sudhaker Makkuni, Janet Dunn, Nicola Barth, and J. Anthony Child*
      Blood 2006;108 2013-2019

    * The molecular classification of multiple myeloma
http://www.bloodjournal.org/cgi/con...ourcetype=HWCIT
      Fenghuang Zhan, Yongsheng Huang, Simona Colla, James P. Stewart, Ichiro Hanamura, Sushil Gupta, Joshua Epstein, Shmuel Yaccoby, Jeffrey Sawyer, Bart Burington, Elias Anaissie, Klaus Hollmig, Mauricio Pineda-Roman, Guido Tricot*, Frits van Rhee, Ronald Walker, Maurizio Zangari, John Crowley*, Bart Barlogie*, and John D. Shaughnessy, Jr
      Blood 2006;108 2020-2028





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

 IMF Myeloma Minute - August 14, 2006
http://readtheminute.myeloma.org/

    *

      Kosan Biosciences Selects Nonproprietary Compound Name For Its Lead Hsp90 Inhibitor Compound
http://www.kosan.com/news_view_pr.cfm?id=291
      Tanespimycin (aka KOS-953) is in a Phase Ib trial in combination with Velcade for multiple myeloma, and is in a Phase I trial as a single agent in multiple myeloma. Tanespimycin has been granted orphan drug status in multiple myeloma in the US and in Europe. (from Kosan Biosciences)

    * Gain of 1q21 in multiple myeloma: from bad to worse?
http://www.bloodjournal.org/cgi/content/full/108/5/1426?etoc
      Pieter Sonneveld*
      Blood 2006;108 1426-1427

    * Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation
http://www.bloodjournal.org/cgi/content/abstract/108/5/1724?etoc
      Ichiro Hanamura, James P. Stewart, Yongsheng Huang, Fenghuang Zhan, Madhumita Santra, Jeffrey R. Sawyer, Klaus Hollmig, Maurizio Zangarri, Mauricio Pineda-Roman, Frits van Rhee, Federica Cavallo, Bart Burington, John Crowley*, Guido Tricot*, Bart Barlogie*, and John D. Shaughnessy, Jr
      Blood 2006;108 1724-1732

    * Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma
http://www.bloodjournal.org/cgi/content/abstract/108/5/1661?etoc
      Angelo Vacca, Claudio Scavelli, Guido Serini, Giulia Di Pietro, Teresa Cirulli, Francesca Merchionne, Domenico Ribatti, Federico Bussolino, Diego Guidolin, Giovanna Piaggio, Andrea Bacigalupo, and Franco Dammacco*
      Blood 2006;108 1661-1667

    * Multiple myeloma cell survival relies on high activity of protein kinase CK2
http://www.bloodjournal.org/cgi/content/abstract/108/5/1698?etoc
      Francesco A. Piazza, Maria Ruzzene, Carmela Gurrieri, Barbara Montini, Luca Bonanni, Gino Chioetto, Giovanni Di Maira, Francesca Barbon, Anna Cabrelle, Renato Zambello, Fausto Adami, Livio Trentin, Lorenzo A. Pinna, and Gianpietro Semenzato
      Blood 2006;108 1698-1707

    * Integration of global SNP-based mapping and _expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma
http://www.bloodjournal.org/cgi/content/abstract/108/5/1733?etoc
      Brian A. Walker, Paola E. Leone, Matthew W. Jenner, Cheng Li, David Gonzalez, David C. Johnson*, Fiona M. Ross, Faith E. Davies*, and Gareth J. Morgan*
      Blood 2006;108 1733-1743

    * Mcl-1L cleavage is involved in TRAIL-R1- and TRAIL-R2-mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells
http://www.bloodjournal.org/cgi/content/abstract/108/4/1346?etoc
      Emmanuelle Menoret, Patricia Gomez-Bougie, Alexandrine Geffroy-Luseau, Sylvanne Daniels, Philippe Moreau, Steven Le Gouill, Jean-Luc Harousseau*, Regis Bataille*, Martine Amiot, and Catherine Pellat-Deceunynck
      Blood 2006;108 1346-1352

    * Successful treatment of AL amyloidosis patients over age 65 with high-dose melphalan and autologous stem cell transplantation
http://www.bloodjournal.org/cgi/con...006-06-029728v1
      David C. Seldin, Jennifer J. Anderson, Martha Skinner, Karim Malek, Daniel G. Wright, Karen Quillen, Kathleen Finn, Betul Oran, and Vaishali Sanchorawala
      Blood published 22 August 2006, 10.1182/blood-2006-06-029728

    * Optimizing immunotherapy in multiple myeloma: restoring the function of patient's monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in the progenitor cells
http://www.bloodjournal.org/cgi/con...006-04-016980v1
      Siqing Wang, Sungyoul Hong, Jing Yang, Jianfei Qian, Xiang Zhang, Elizabeth Shpall, Larry W Kwak, and Qing Yi
      Blood published 17 August 2006, 10.1182/blood-2006-04-016980

    * ABCG2 _expression, function and promoter methylation in human multiple myeloma
http://www.bloodjournal.org/cgi/con...005-10-009084v1
      Joel G Turner, Jana L. Gump, Chunchun Zhang, James M. Cook, Douglas Marchion, Lori Hazlehurst, Pamela Munster, Michael J. Schell, William S. Dalton, and Daniel M. Sullivan
      Blood published 17 August 2006, 10.1182/blood-2005-10-009084

    *

      Thymoglobulin targets multiple plasma cell antigens and has in vitro and in vivo activity in multiple myeloma.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
      Timm MM, Kimlinger TK, Haug JL, Kline MP, Greipp PR, Rajkumar SV*, Kumar SK.
      Leukemia. 2006 Aug 17; [Epub ahead of print]





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

Myeloma Minute - August 6, 2006
http://readtheminute.myeloma.org/

Maintenance therapy with thalidomide improves survival in multiple myeloma
patients
http://www.bloodjournal.org/cgi/con...006-05-022962v1
Michel Attal*, Jean-Luc Harousseau*, Serge Leyvraz, Chantal Doyen, Cyrille Hulin, Lofti Benboubker, Ibrahim Yakoub Agha, Jean-Henri Bourhis, Laurent Garderet, Brigitte Pegourie, Charles Dumontet, Marc Renaud, Laurent Voillat, Christian Berthou, Gerald Marit, Mathieu Monconduit, Denis Caillot, Bernard Grobois, Herve Avet-Loiseau*, Philippe Moreau, and Thierry Facon
Blood published 27 July 2006, 10.1182/blood-2006-05-022962

Drug Fights Multiple Myeloma by Putting "Brakes" on Cell Proliferation
http://www.newswise.com/articles/view/522418/
Researchers at the Weill Medical College of Cornell University in New York City report that an experimental drug targeted to a cancer-causing mechanism within the cell may be a powerful weapon against deadly multiple myeloma. Animal studies using human myeloma cell lines show that the experimental agent -- called PD 0332991, an orally active, small molecule -- inhibits specific enzymes and proteins that dysregulate the cell's division and expansion. (from Newswise)





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Mieloma Novedades en investigacion julio a septiembre 2006

Fuente y mas informacion:

Myeloma Minute - July 26, 2006
http://readtheminute.myeloma.org/

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Muller CI, Kumagai T, O'kelly J, Seeram NP, Heber D, Koeffler HP.
Leuk Res. 2006 Jul;30(7):841-8. Epub 2006 Jan 19.


Vascular Targeted Photodynamic Therapy (VTP): A New Modality that Cuts Off the Tumor Blood Supply (in PDF format)
http://www.weizmann.ac.il/Biology/o...r/y_salomon.pdf
Salomon, Y, et al.
Weizmann Institute of Science, Rehovot, Israel


Osteonecrosis of the jaw
http://www.haematologica.org/preprint/20060601/03906078_9641.pdf
Meletios A. Dimopoulos, Efstathios Kastritis, Athanasios Anagnostopoulos, Ioannis Melakopoulos, Dimitra Gika, Lia A. Moulopoulos, Christina Bamia, Evangelos Terpos, Konstantinos Tsionos, Aristotelis Bamias
haematologica 2006;91:968-971


AnorMed begins multiple myeloma trial
http://www.upi.com/HealthBusiness/v...10-094642-4008r
The company said it has recruited 300 patients for a phase 3 study of the therapy for multiple myeloma to assess Mozobil in a standard stem cell mobilization regimen.


Human Genome Sciences Begins Randomized Phase 2 Clinical Trial Of HGS-ETR1 In Combination With Bortezomib
http://biz.yahoo.com/prnews/060720/sfth054.html?.v=60
 (from Yahoo Finance)

Tumor suppressor p16 methylation in multiple myeloma: biological and
clinical implications
http://www.bloodjournal.org/cgi/con...006-05-024661v1
Natalia Gonzalez-Paz, Wee J Chng, Rebecca F McClure, Emily Blood, Martin M Oken*, Brian Van Ness*, C D James, Paul J Kurtin, Kimberly Henderson, Gregory J Ahmann, Morie Gertz*, Martha Lacy, Angela Dispenzieri, Philip R Greipp, and Rafael Fonseca*
Blood published 13 July 2006, 10.1182/blood-2006-05-024661

A randomized phase 2 study of lenalidomide therapy for  patients with relapsed or relapsed and refractory  multiple myeloma
http://www.bloodjournal.org/cgi/con...006-04-015909v2
Paul G Richardson*, Emily Blood, Constantine S Mitsiades, Sundar Jagannath*, Steven R Zeldenrust, Melissa Alsina, Robert L Schlossman, SV Rajkumar*, K R Desikan, Teru Hideshima, Nikhil C Munshi, Kathleen Kelly-Colson, Deborah Doss, Mary L McKenney, Svetlana Gorelik, Diane Warren, Andrea Freeman, Rebecca Rich, A. Wu, M Olesnyckyj, K Wride, William S Dalton, Jerome Zeldis, Robert Knight, Edie Weller, and Kenneth C Anderson*
Blood published 13 July 2006, 10.1182/blood-2006-04-015909





____________
Un saludo
Victor Quesada
Webmaster y Administrador de Mieloma.com

Guia de Uso - http://www.mieloma.com/ayuda/

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.