Novedades en investigacion marzo 2006

Fuente:
The Myeloma Minute - March 8, 2006

http://readtheminute.myeloma.org/


Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
http://www.bloodjournal.org/cgi/con...-08-3531v1?etoc
Esther A Obeng, Louise M Carlson, Delia M Gutman, William J Harrington, Jr., Kelvin P Lee, and Lawrence H Boise
Blood published 28 February 2006, 10.1182/blood-2005-08-3531


Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Roccaro AM, Hideshima T, Raje N, Kumar S, Ishitsuka K, Yasui H, Shiraishi N, Ribatti D, Nico B, Vacca A, Dammacco F, Richardson PG*, Anderson KC*.
Cancer Res. 2006 Jan 1;66(1):184-91.


Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Tai YT, Li XF, Catley L, Coffey R, Breitkreutz I, Bae J, Song W, Podar K, Hideshima T, Chauhan D, Schlossman R, Richardson P*, Treon SP, Grewal IS, Munshi NC, Anderson KC*.
Cancer Res. 2005 Dec 15;65(24):11712-20.


Immunomodulatory analogues of thalidomide in the treatment of multiple myeloma.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Suppiah R, Srkalovic JG, Hussein MA.
Clin Lymphoma Myeloma. 2006 Jan;6(4):301-5.


Adenoviral-mediated transfer of human wild-type p53, GM-CSF and B7-1 genes results in growth suppression and autologous anti-tumor cytotoxicity of multiple myeloma cells in vitro.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Ren SP, Wu CT, Huang WR, Lu ZZ, Jia XX, Wang L, Lao MF, Wang LS.
Cancer Immunol Immunother. 2006 Apr;55(4):375-85. Epub 2005 Jul 2.


Treatment of Bendamustine and Prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with Melphalan and Prednisone-a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO).
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Ponisch W, Mitrou PS, Merkle K, Herold M, Assmann M, Wilhelm G, Dachselt K, Richter P, Schirmer V, Schulze A, Subert R, Harksel B, Grobe N, Stelzer E, Schulze M, Bittrich A, Freund M, Pasold R, Friedrich T, Helbig W, Niederwieser D.
J Cancer Res Clin Oncol. 2006 Apr;132(4):205-12. Epub 2006 Jan 10.


Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Shimizu T, Nakazato T, Xian MJ, Sagawa M, Ikeda Y, Kizaki M.
Biochem Pharmacol. 2006 Mar 14;71(6):742-50. Epub 2006 Jan 19.


Circulating fragmented nucleosomal DNA and caspase-3 mRNA in patients with lymphoma and myeloma.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Deligezer U, Erten N, Akisik EE, Dalay N.
Exp Mol Pathol. 2006 Feb;80(1):72-6. Epub 2005 Jun 15.





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