* Corso A,
* Varettoni M,
* Zappasodi P,
* Klersy C,
* Mangiacavalli S,
* Pica G,
* Lazzarino M.
1Institute of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
La Osteonecrosis del menton (ONJ) es una complicación conocida del uso de bisfosfonatos. La incidencia se extiende entre 6 y el 13% y parece ser más alta en la gente tratada con el ácido zoledronico (ZA) que con el pamidronato.
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Una pauta reducida de ZA puede ser más segura que la pauta estándar mientras que mantiene su eficacia anti-resortiva.
Fuente y mas informacion:
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Cita:A different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myeloma.
* Corso A,
* Varettoni M,
* Zappasodi P,
* Klersy C,
* Mangiacavalli S,
* Pica G,
* Lazzarino M.
1Institute of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Osteonecrosis of the jaw (ONJ) is a reported complication of bisphosphonate use. The incidence ranges between 6 and 13% and seems to be higher in people treated with zoledronic acid (ZA) than with pamidronate. We retrospectively evaluated the incidences of ONJ and skeletal-related events (SRE) in 106 patients with multiple myeloma divided in two groups according to the schedule of administration of bisphosphonates: 51 received monthly administrations until tolerated (group A, standard schedule), 55 were treated monthly during the first year and then every 3 months (group B, reduced schedule). The incidence of SRE was similar (15.1 per 100 person years in group A and 17.7 in group B). ONJ occurred in seven patients, six in group A and one in group B (P=0.049). The risk of ONJ was eight-fold lower with the reduced schedule than with the standard schedule. The only significant risk factor for ONJ was the type of bisphosphonate (P=0.006). The incidence of ONJ was significantly higher with ZA than with pamidronate + ZA (9.1 vs 1.6 per 100 person-years). No ONJ was observed in patients treated only with pamidronate. A reduced schedule of ZA may be safer than the standard schedule while maintaining anti-resorptive efficacy.Leukemia advance online publication, 5 April 2007; doi:10.1038/sj.leu.2404682.
PMID: 17410188 [PubMed - as supplied by publisher]
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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html
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