Mieloma Multiple - Mieloma.com

Fuente y mas informacion:

MYELOMA MINUTE - FEBRUARY 21, 2007
http://readtheminute.myeloma.org/

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      Morphoproteomic Expression of H-ras (p21ras) Correlates with Serum Monoclonal Immunoglobulin Reduction in Multiple Myeloma Patients Following Pamidronate Treatment
http://www.annclinlabsci.org/cgi/content/abstract/37/1/34
      Ping L. Zhang, Albert T. Quiery, Jr., Thomas M. Blasick and Robert E. Brown
      Annals of Clinical & Laboratory Science 37:34-38 (2007)

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      CKS1B, over expressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and independent mechanisms
http://bloodjournal.hematologylibra...006-07-038703v1
      Fenghuang Zhan, Simona Colla, Xiaosong Wu, James P Stewart, W. Michael Kuehl, Bart Barlogie*, and John D. Shaughnessy, Jr.
      Blood published 15 February 2007, 10.1182/blood-2006-07-038703

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      Nur77 converts phenotype of Bcl-B, an anti-apoptotic protein expressed in plasma cells and myeloma
http://bloodjournal.hematologylibra...56879v2?papetoc
      Frederic Luciano, Maryla Krajewska, Paulina Ortiz-Rubio, Stan Krajewski, Dayong Zhai, Benjamin Faustin, Jean-Marie Bruey, Beatrice Bailly-Maitre, Alan Lichtenstein, Siva Kumar Kolluri, Arnold C Satterthwait, Xiao-Kun Zhang, and John C Reed
      Blood published 13 February 2007, 10.1182/blood-2006-11-056879

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      Bortezomib enhances dendritic cell (DC) mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
http://bloodjournal.hematologylibra...54221v1?papetoc
      Radek Spisek, Anna Charalambous, Amitabha Mazumder, David H. Vesole*, Sundar Jagannath*, and Madhav V Dhodapkar
      Blood published 13 February 2007, 10.1182/blood-2006-10-054221

      Read related article: A chemotherapy drug packs a one-two punch.
http://newswire.rockefeller.edu/?page=engine&id=594
 New research by Rockefeller University associate professor Madhav Dhodapkar shows that bortezomib kills tumor cells in such a way that it may allow the immune system to recognize them. (from Rockefeller University Newswire)

    * CD28-mediated regulation of multiple myeloma cell proliferation and survival
http://bloodjournal.hematologylibra...006-03-012542v1
      Nizar Jacques Bahlis, Anne M. King, Despina Kolonias, Louise M Carlson, Hong Yu Liu, Mohamad A Hussein, Howard R Terebelo, Gerald E Byrne, Jr, Bruce L Levine, Lawrence H Boise, and Kelvin P Lee
      Blood published 20 February 2007, 10.1182/blood-2006-03-012542

    * Advances in myeloma therapy: breaking the cycle
http://bloodjournal.hematologylibra...hort/109/5/1798
      Carl Gregory
      Blood 2007;109 1798

    * 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4
http://bloodjournal.hematologylibra...ract/109/5/2089
      Suk Hang Cheng, Margaret H. L. Ng, Kin Mang Lau, Herman S. Y. Liu, Joyce C. W. Chan, Angela B. Y. Hui, Kwok Wai Lo, Hua Jiang, Jian Hou, Raymond W. Chu, Wai Shan Wong, Natalie P. H. Chan,, and Ho Keung Ng
      Blood 2007;109 2089-2099

    * Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
http://bloodjournal.hematologylibra...ract/109/5/2100
      Christian Jakob, Karl Egerer, Peter Liebisch, Seval Turkmen, Ivana Zavrski, Ulrike Kuckelkorn, Ulrike Heider, Martin Kaiser, Claudia Fleissner, Jan Sterz, Lorenz Kleeberg, Eugen Feist, Gerd-R. Burmester, Peter-M. Kloetzel, and Orhan Sezer*
      Blood 2007;109 2100-2105

    * Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
http://bloodjournal.hematologylibra...ract/109/5/2106
      Shmuel Yaccoby, Wen Ling, Fenghuang Zhan, Ronald Walker, Bart Barlogie*, and John D. Shaughnessy, Jr
      Blood 2007;109 2106-2111

    * SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-{kappa}B activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth
http://bloodjournal.hematologylibra...ract/109/5/2130
      Rentian Feng, Gulsum Anderson, Guozhi Xiao, Gary Elliott, Lorenzo Leoni, Markus Y. Mapara, G. David Roodman, and Suzanne Lentzsch
      Blood 2007;109 2130-2138

    * Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial
http://bloodjournal.hematologylibra...ract/109/5/2250
      Heliton Spindola Antunes, Alexandre Mello de Azevedo, Luiz Fernando da Silva Bouzas, Carlos Alberto Esteves Adao, Claudia Tereza Pinheiro, Renato Mayhe, Lucia Helena Pinheiro, Renato Azevedo, Valkiria D'Aiuto de Matos, Pedro Carvalho Rodrigues, Isabele Avila Small, Renato Amaro Zangaro, and Carlos Gil Ferreira
      Blood 2007;109 2250-2255





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 15 Feb 2007 12:56:07 -0600 (CST)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Feb 6
    Medical management update: Multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Stoopler ET, Vogl DT, Stadtmauer EA

    Blood Rev. 2007 Feb 9
    Farnesyltransferase inihibitors in hematologic malignancies
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Harousseau JL

    Eur J Haematol. 2007 Feb 5
    Thalidomide-dexamethasone plus pegylated liposomal doxorubicin vs. thalidomide-dexamethasone: a case-matched study in advanced multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Offidani M, Bringhen S, Corvatta L, Falco P, Marconi M, Avonto I, Piersantelli MN, Polloni C, Boccadoro M, Leoni P, Palumbo A
    Biol Blood Marrow Transplant. 2007 Feb 1
    Nonmyeloablative Unrelated Donor Hematopoietic Cell Transplantation to Treat Patients with Poor-Risk, Relapsed, or Refractory Multiple Myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Georges GE, Maris MB, Maloney DG, Sandmaier BM, Sorror ML, Shizuru JA, Lange T, Agura ED, Bruno B, McSweeney PA, Pulsipher MA, Chauncey TR, Mielcarek M, Storer BE, Storb R





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:

MYELOMA MINUTE - FEBRUARY 13, 2007
http://readtheminute.myeloma.org/

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      Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
http://bloodjournal.hematologylibra...109/4/1669?etoc
      Klaus Podar, Marc S. Raab, Jing Zhang, Douglas McMillin, Iris Breitkreutz, Yu-Tzu Tai, Boris K. Lin, Nikhil Munshi, Teru Hideshima, Dharminder Chauhan, and Kenneth C. Anderson*
      Blood 2007;109 1669-1677

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      Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
http://bloodjournal.hematologylibra...109/4/1692?etoc
      Fenghuang Zhan, Bart Barlogie*, Varant Arzoumanian, Yongsheng Huang, David R. Williams, Klaus Hollmig, Mauricio Pineda-Roman, Guido Tricot*, Frits van Rhee, Maurizio Zangari, Madhav Dhodapkar, and John D. Shaughnessy, Jr
      Blood 2007;109 1692-1700

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      PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells
http://bloodjournal.hematologylibra...109/4/1712?etoc
      Janelle Sharkey, Tiffany Khong, and Andrew Spencer
      Blood 2007;109 1712-1719

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      Chronic GvHD decreases anti-viral immune responses in allogeneic BMT
http://www.ncbi.nlm.nih.gov/entrez/...t_uids=17289817
      Mohammad S Hossain, John D Roback, Brian P Pollack, David L. Jaye, Amelia Langston, and Edmund K Waller
      Blood published 8 February 2007, 10.1182/blood-2006-04-017442





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 8 Feb 2007 12:44:22 -0600 (CST)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Bone Marrow Transplant. 2007 Jan 29
    Autologous stem cell transplantation is safe and feasible in elderly patients with multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Qazilbash MH, Saliba RM, Hosing C, Mendoza F, Qureshi SR, Weber DM, Wang M, Flosser T, Couriel DR, De Lima M, Kebriaei P, Popat U, Alousi AM, Champlin RE, Giralt SA

    Drugs R D. 2007
    Proteasome Inhibitors in the Clinical Setting: Benefits and Strategies to Overcome Multiple Myeloma Resistance to Proteasome Inhibitors
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Cheriyath V, Jacobs BS, Hussein MA

    Biol Blood Marrow Transplant. 2007 Feb
    High-dose Therapy with Single Autologous Transplantation versus Chemotherapy for Newly Diagnosed Multiple Myeloma: A Systematic Review and Meta-analysis of Randomized Controlled Trials
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Koreth J, Cutler CS, Djulbegovic B, Behl R, Schlossman RL, Munshi NC, Richardson PG, Anderson KC, Soiffer RJ, Alyea EP 3rd
    Clin Cancer Res. 2007 Jan 15
    The Bcl-2 Family Protein Inhibitor, ABT-737, Has Substantial Antimyeloma Activity and Shows Synergistic Effect with Dexamethasone and Melphalan
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Trudel S, Stewart AK, Li Z, Shu Y, Liang SB, Trieu Y, Reece D, Paterson J, Wang D, Wen XY





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:

MYELOMA MINUTE - February 3, 2007
http://readtheminute.myeloma.org/

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      Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
http://bloodjournal.hematologylibra...109/3/1103?etoc
      Djordje Atanackovic, Julia Arfsten, Yanran Cao, Sacha Gnjatic, Frank Schnieders, Katrin Bartels, Georgia Schilling, Christiane Faltz, Christine Wolschke, Judith Dierlamm, Gerd Ritter, Thomas Eiermann, Dieter Kurt Hossfeld, Axel R. Zander, Achim A. Jungbluth, Lloyd J. Old, Carsten Bokemeyer, and Nicolaus Kroger
      Blood 2007;109 1103-1112

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      Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)
http://bloodjournal.hematologylibra...109/3/1220?etoc
      Dharminder Chauhan, Paola Neri, Mugdha Velankar, Klaus Podar, Teru Hideshima, Mariateresa Fulciniti, Pierfrancesco Tassone, Noopur Raje, Constantine Mitsiades, Nicholas Mitsiades, Paul Richardson*, Leigh Zawel, Mary Tran, Nikhil Munshi, and Kenneth C. Anderson*
      Blood 2007;109 1220-1227

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      Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications
http://bloodjournal.hematologylibra...109/3/1228?etoc
      Natalia Gonzalez-Paz, Wee J. Chng, Rebecca F. McClure, Emily Blood, Martin M. Oken*, Brian Van Ness*, C. David James, Paul J. Kurtin, Kimberly Henderson, Gregory J. Ahmann, Morie Gertz*, Martha Lacy, Angela Dispenzieri, Philip R. Greipp, and Rafael Fonseca*
      Blood 2007;109 1228-1232

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      The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
http://bloodjournal.hematologylibra...56747v1?papetoc
      Simona Colla, Fenghuang Zhan, Wei Xiong, Xiaosong Wu, Hongwei Xu, Owen Stephens, Shmuel Yaccoby, Joshua Epstein, Bart Barlogie*, and John D Shaughnessy, Jr.
      Blood published 25 January 2007, 10.1182/blood-2006-11-056747





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 1 Feb 2007 13:01:02 -0600 (CST)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Blood. 2007 Jan 25
    The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Colla S, Zhan F, Xiong W, Wu X, Xu H, Stephens O, Yaccoby S, Epstein J, Barlogie B, Shaughnessy JD Jr

    Br J Haematol. 2007 Jan
    A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma: NCIC CTG MY.7
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Shustik C, Belch A, Robinson S, Rubin SH, Dolan SP, Kovacs MJ, Grewal KS, Walde D, Barr R, Wilson J, Gill K, Vickars L, Rudinskas L, Sicheri DA, Wilson K, Djurfeldt M, Shepherd LE, Ding K, Meyer RM

    Oncologist. 2007 Jan
    Final Report of Toxicity and Efficacy of a Phase II Study of Oral Cyclophosphamide, Thalidomide, and Prednisone for Patients with Relapsed or Refractory Multiple Myeloma: A Hoosier Oncology Group Trial, HEM01-21
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Suvannasankha A, Fausel C, Juliar BE, Yiannoutsos CT, Fisher WB, Ansari RH, Wood LL, Smith GG, Cripe LD, Abonour R





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 22 Mar 2007 12:50:43 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    J Natl Compr Canc Netw. 2007 Feb
    The emerging role of novel therapies for the treatment of relapsed myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Richardson PG, Hideshima T, Mitsiades C, Anderson KC

    Clin Adv Hematol Oncol. 2007 Feb
    What is the significance of molecular remission in multiple myeloma?
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Tricot GJ

    Expert Rev Anticancer Ther. 2007 Mar
    Thrombosis in multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Zangari M, Elice F, Fink L, Tricot G

    J Natl Compr Canc Netw. 2007 Feb
    Multiple myeloma: most common end-organ damage and management
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Hussein MA

    Mayo Clin Proc. 2007 Mar
    Treatment of newly diagnosed multiple myeloma based on mayo stratification of myeloma and risk-adapted therapy (mSMART): consensus statement
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Dispenzieri A, Rajkumar SV, Gertz MA, Fonseca R, Lacy MQ, Bergsagel PL, Kyle RA, Greipp PR, Witzig TE, Reeder CB, Lust JA, Russell SJ, Hayman SR, Roy V, Kumar S, Zeldenrust SR, Dalton RJ, Stewart AK





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Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Fuente y mas informacion:
Thu, 15 Mar 2007 12:58:42 -0500 (CDT)
De:    "MMRF SmartBrief "
http://www.multiplemyeloma.org/

    Leuk Lymphoma. 2007 Feb
    Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Eleutherakis-Papaiakovou V, Bamias A, Gika D, Simeonidis A, Pouli A, Anagnostopoulos A, Michali E, Economopoulos T, Zervas K, Group MA

    Leuk Lymphoma. 2007 Jan
    An analysis of clinical trials assessing the efficacy and safety of single-agent thalidomide in patients with relapsed or refractory multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Prince HM, Schenkel B, Mileshkin L

    Leuk Res. 2007 Feb 23
    High dose melphalan or intermediate dose melphalan can be well tolerated and result in good response rates in selected elderly patients with myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Bishton M, Gilyead M, Das Gupta E, Williams C, Russell NH, Byrne JL

    Leukemia. 2007 Mar 8
    Maintenance therapy in multiple myeloma
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Mihelic R, Kaufman JL, Lonial S





____________
Guia de Uso - http://www.mieloma.com/v2/uso-del-foro-vf27.html

Ser feliz no significa que todo sea perfecto, quiere decir que has decidido seguir adelante pese a las dificultades.

Que cantidad de informaciones!
Gracias por molestarte tanto!